Effects of voluntary wheel running on LPS-induced sickness behavior in aged mice
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چکیده
منابع مشابه
Voluntary wheel running attenuates lipopolysaccharide-induced liver inflammation in mice.
Sepsis induces an acute inflammatory response in the liver, which can lead to organ failure and death. Given the anti-inflammatory effects of exercise, we hypothesized that habitual physical activity could protect against acute sepsis-induced liver inflammation via mechanisms, including heat shock protein (HSP) 70/72. Male C57BL/6J mice (n = 80, ∼8 wk of age) engaged in physical activity via vo...
متن کاملVoluntary wheel running does not affect lipopolysaccharide-induced depressive-like behavior in young adult and aged mice.
OBJECTIVE(S) Peripheral stimulation of the innate immune system with lipopolysaccharide (LPS) causes prolonged depressive-like behavior in aged mice that is dependent on indoleamine 2,3 dioxygenase (IDO) activation. Regular moderate-intensity exercise training has been shown to exert neuroprotective effects that might reduce depressive-like behavior in aged mice. The purpose of this study was t...
متن کاملNeuroprotective effects of voluntary wheel running and eriobotrya japonica flower extract on Parkinsonian rats
Backgrounds: The loss of dopamine-secreting cells and the decrease in the status of antioxidant is associated with incidents of Parkinson's disease. The purpose of the present study was to determine the protective effect of a 12- weeks voluntary wheel running (VWR) along with the injection of eriobotrya japonica flower extract (EJFE, 200 mg/kg body weight, 3 days a week) on cer...
متن کاملMEMRI Study of Mice Cerebellar Activation after Voluntary Wheel Running
INTRODUCTION: There is increasing interest in studying functional and cellular effects of environmental stimuli for better intervention in neurological rehabilitation [1, 2]. Recent studies have been using BOLD-fMRI to detect the neural activity in living animals [3] and human [4]. However it is technically difficult to apply BOLD-fMRI to nonrestrained animals due to its extreme susceptibility ...
متن کاملNeurobiology of Mice Selected for High Voluntary Wheel-running Activity.
Selective breeding of house mice has been used to study the evolution of locomotor behavior. Our model consists of 4 replicate lines selectively bred for high voluntary wheel running (High-Runner) and 4 bred randomly (Control). The major changes in High-Runner lines appear to have taken place in the brain rather than in capacities for exercise. Their neurobiological profile resembles features o...
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ژورنال
عنوان ژورنال: Brain, Behavior, and Immunity
سال: 2013
ISSN: 0889-1591
DOI: 10.1016/j.bbi.2012.12.014